In November 2016, Griffin attacked Britney Spears for her alleged mental illness during an awkward interview with Larry King, who seemed less than amused by the comedienne's commentary.

"I used to make fun of Britney Spears... Did you get the pinwheel eyes? You know what I'm talking about. She's not all there" Griffin told a confused King.

King responded, "So what's your point? What point are you trying to make here?"

Griffin replied, "I'm saying that I hope you were gentle with her, because she's a fragile ... sorry, I just wanted to know if you got through to her in a way that her doctors couldn't."

It seems like Griffin was just bitter that she didn't make a lasting impression on the "Baby One More Time" singer. She explained, "I actually appeared in her Vegas show. She has someone every night come up, and they put a harness on me, and I was her sex slave for a song that she sings called 'Freakshow' ... I've known her since she was 16 — so I thought, at the end, we're onstage, it's a triumphant moment for really both of us. And then I thought, 'She's going to want to say, 'Good to see you again,' and I say, 'Brit, it's so great to see you.' She didn't know who I was. Then her gay backup dancer from heaven said, 'Kathy Griffin.' And she said, 'Give it up for Kathy, y'all!' And that's all I ask, Britney."

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