George went on the stage at the age of 3 and toured the United States, appearing with her parents. She starred on stage in the 1920s, although she had made several films in the early part of that decade. She starred in Personal Appearance, a comedy by Lawrence Riley. This role was reprised by Mae West in the classic film, Go West, Young Man, which West adapted from the play. In 1936 George was nominated for an Academy Award for Best Actress for Valiant Is the Word for Carrie.

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